作者
Christopher AB Kowalewski, Fatemah Shenasa, Miguel Rodrigo, Paul Clopton, Gabriela Meckler, Mahmood I Alhusseini, Mark A Swerdlow, Vijay Joshi, Samir Hossainy, Junaid AB Zaman, Tina Baykaner, Albert J Rogers, Johannes Brachmann, John M Miller, David E Krummen, William H Sauer, Nicholas S Peters, Paul J Wang, Sanjiv M Narayan
发表日期
2018/6
期刊
Circulation: Arrhythmia and Electrophysiology
卷号
11
期号
6
页码范围
e005846
出版商
Lippincott Williams & Wilkins
简介
Background
Mechanisms for persistent atrial fibrillation (AF) are unclear. We hypothesized that putative AF drivers and disorganized zones may interact dynamically over short time scales. We studied this interaction over prolonged durations, focusing on regions where ablation terminates persistent AF using 2 mapping methods.
Methods
We recruited 55 patients with persistent AF in whom ablation terminated AF prior to pulmonary vein isolation from a multicenter registry. AF was mapped globally using electrograms for 360±45 cycles using (1) a published phase method and (2) a commercial activation/phase method.
RESULTS
Patients were 62.2±9.7 years, 76% male. Sites of AF termination showed rotational/focal patterns by methods 1 and 2 (51/55 vs 55/55; P=0.13) in spatially conserved regions, yet fluctuated over time. Time points with no AF driver showed competing drivers elsewhere or disordered waves …
学术搜索中的文章
CAB Kowalewski, F Shenasa, M Rodrigo, P Clopton… - Circulation: Arrhythmia and Electrophysiology, 2018