作者
Theo GM Van Erp, Esther Walton, Derrek P Hibar, Lianne Schmaal, Wenhao Jiang, David C Glahn, Godfrey D Pearlson, Nailin Yao, Masaki Fukunaga, Ryota Hashimoto, Naohiro Okada, Hidenaga Yamamori, Juan R Bustillo, Vincent P Clark, Ingrid Agartz, Bryon A Mueller, Wiepke Cahn, Sonja Mc De Zwarte, Hilleke E Hulshoff Pol, René S Kahn, Roel A Ophoff, Neeltje Em Van Haren, Ole A Andreassen, Anders M Dale, Nhat Trung Doan, Tiril P Gurholt, Cecilie B Hartberg, Unn K Haukvik, Kjetil N Jørgensen, Trine V Lagerberg, Ingrid Melle, Lars T Westlye, Oliver Gruber, Bernd Kraemer, Anja Richter, David Zilles, Vince D Calhoun, Benedicto Crespo-Facorro, Roberto Roiz-Santiañez, Diana Tordesillas-Gutiérrez, Carmel Loughland, Vaughan J Carr, Stanley Catts, Vanessa L Cropley, Janice M Fullerton, Melissa J Green, Frans A Henskens, Assen Jablensky, Rhoshel K Lenroot, Bryan J Mowry, Patricia T Michie, Christos Pantelis, Yann Quidé, Ulrich Schall, Rodney J Scott, Murray J Cairns, Marc Seal, Paul A Tooney, Paul E Rasser, Gavin Cooper, Cynthia Shannon Weickert, Thomas W Weickert, Derek W Morris, Elliot Hong, Peter Kochunov, Lauren M Beard, Raquel E Gur, Ruben C Gur, Theodore D Satterthwaite, Daniel H Wolf, Aysenil Belger, Gregory G Brown, Judith M Ford, Fabio Macciardi, Daniel H Mathalon, Daniel S O’leary, Steven G Potkin, Adrian Preda, James Voyvodic, Kelvin O Lim, Sarah McEwen, Fude Yang, Yunlong Tan, Shuping Tan, Zhiren Wang, Fengmei Fan, Jingxu Chen, Hong Xiang, Shiyou Tang, Hua Guo, Ping Wan, Dong Wei, Henry J Bockholt, Stefan Ehrlich, Rick PF Wolthusen, Margaret D King, Jody M Shoemaker, Scott R Sponheim, Lieuwe De Haan, Laura Koenders, Marise W Machielsen, Therese Van Amelsvoort, Dick J Veltman, Francesca Assogna, Nerisa Banaj, Pietro De Rossi, Mariangela Iorio, Fabrizio Piras, Gianfranco Spalletta, Peter J McKenna, Edith Pomarol-Clotet, Raymond Salvador, Aiden Corvin, Gary Donohoe, Sinead Kelly, Christopher D Whelan, Erin W Dickie, David Rotenberg, Aristotle N Voineskos, Simone Ciufolini, Joaquim Radua, Paola Dazzan, Robin Murray, Tiago Reis Marques, Andrew Simmons, Stefan Borgwardt, Laura Egloff, Fabienne Harrisberger, Anita Riecher-Rössler, Renata Smieskova, Kathryn I Alpert, Lei Wang, Erik G Jönsson, Sanne Koops, Iris EC Sommer, Alessandro Bertolino, Aurora Bonvino, Annabella Di Giorgio, Emma Neilson, Andrew R Mayer, Julia M Stephen, Jun Soo Kwon, Je-Yeon Yun, Dara M Cannon, Colm McDonald, Irina Lebedeva, Alexander S Tomyshev, Tolibjohn Akhadov, Vasily Kaleda, Helena Fatouros-Bergman
发表日期
2018/11/1
期刊
Biological psychiatry
卷号
84
期号
9
页码范围
644-654
出版商
Elsevier
简介
Background
The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.
Methods
The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11–78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10–87 years; 53% male) assessed with standardized methods at 39 centers worldwide.
Results
Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen’s d = −0.530/−0.516) and smaller surface area (left/right hemisphere: Cohen’s d = −0.251/−0.254), with the …
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TGM Van Erp, E Walton, DP Hibar, L Schmaal, W Jiang… - Biological psychiatry, 2018