作者
Jonas B Nielsen, Jørgen T Kühl, Adrian Pietersen, Claus Graff, Bent Lind, Johannes J Struijk, Morten S Olesen, Moritz F Sinner, Troels N Bachmann, Stig Haunsø, Børge G Nordestgaard, Patrick T Ellinor, Jesper H Svendsen, Klaus F Kofoed, Lars Køber, Anders G Holst
发表日期
2015/9/1
期刊
Heart Rhythm
卷号
12
期号
9
页码范围
1887-1895
出版商
Elsevier
简介
Background
Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting.
Objective
The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF.
Methods
Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries.
Results
A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100–105 ms), individuals with very short (≤89 ms; hazard ratio [HR] 1.60, 95% confidence interval …
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JB Nielsen, JT Kühl, A Pietersen, C Graff, B Lind… - Heart Rhythm, 2015