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Patients with epilepsy are at increased risk of premature death from all causes and likely also from sudden unexplained death (SUD). Many patients with epilepsy have significant comorbidity, and it is unclear how much of the increased risk can be explained by epilepsy itself. We aimed to chart the incidence of sudden unexpected death in epilepsy (SUDEP) and estimate the risk of death from all causes and SUD conferred by epilepsy independently.

We conducted a historical cohort study using data from Danish registries and a complete manual review of all death certificates. The population studied consisted of all Danish residents in the age group 1–35 years, in the period 2000–2006 (inclusive), and the main outcome measures were risk of death and SUD.

We identified 33,022 subjects with epilepsy (median follow‐up 3.7 years) and 3,001,952 subjects without (median follow …