作者
Ricard Cervera, Jean‐Charles Piette, Josep Font, Munther A Khamashta, Yehuda Shoenfeld, María Teresa Camps, Soren Jacobsen, Gabriella Lakos, Angela Tincani, Irene Kontopoulou‐Griva, Mauro Galeazzi, Pier Luigi Meroni, Ronald HWM Derksen, Philip G De Groot, Erika Gromnica‐Ihle, Marta Baleva, Marta Mosca, Stefano Bombardieri, Frédéric Houssiau, Jean‐Christophe Gris, Isabelle Quéré, Eric Hachulla, Carlos Vasconcelos, Beate Roch, Antonio Fernández‐Nebro, Marie‐Claire Boffa, Graham RV Hughes, Miguel Ingelmo
发表日期
2002/4
期刊
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
卷号
46
期号
4
页码范围
1019-1027
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression.
Methods
The clinical and serologic features of APS (Sapporo preliminary criteria) in 1,000 patients from 13 European countries were analyzed using a computerized database.
Results
The cohort consisted of 820 female patients (82.0%) and 180 male patients (18.0%) with a mean ± SD age of 42 ± 14 years at study entry. “Primary” APS was present in 53.1% of the patients; APS was associated with systemic lupus erythematosus (SLE) in 36.2%, with lupus‐like syndrome in 5.0%, and with other diseases in 5.9%. A variety of thrombotic manifestations affecting the majority of organs were recorded. A catastrophic APS occurred in 0.8% of the patients. Patients with APS associated with SLE had more episodes of arthritis and livedo reticularis …
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R Cervera, JC Piette, J Font, MA Khamashta… - Arthritis & Rheumatism: Official Journal of the American …, 2002
