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Background: Ovarian cancer is the fifth leading cause of cancer death in women and the most lethal gynecologic malignancy with a rate of survival of 40%. Aberrant GAS6-AXL signaling pathways are associated with many human diseases, including bone diseases, immune-suppression, fibrosis, cancer progression and metastasis. Experimental evidences demonstrated that patients expressing high levels of Axl shows shorter over-survival than patients expressing low levels of Axl in epithelial ovarian cancer. Therefore, there is the need to find novel strategies for silencing and blocking this signaling pathway and the dissemination of ovarian cancer.

Methods: In this study we hypothesized that dithiophosphate modified AXL-aptamers lead long-lasting bio-disponibility and high stability, resulting in decreased migration, and proliferation. We synthetized and screened a library of 17 aptamers that differ in the position of …