作者
Antonio Greco, Andrea Gallo, Massimo Fusconi, Caterina Marinelli, GF Macri, Marco de Vincentiis
发表日期
2012/8/1
来源
Autoimmunity reviews
卷号
11
期号
10
页码范围
731-738
出版商
Elsevier
简介
OBJECTIVES
To review our current knowledge of the pathogenesis of Meniere's disease, including viral infection and immune system-mediated mechanisms, and to discuss the pathogenesis as it relates to pharmacotherapy.
SYSTEMATIC REVIEW METHODOLOGY
Relevant publications on the aetiopathogenesis, molecular biology, genetics and histopathology of Meniere's disease from 1861 to 2011 were analysed.
RESULTS AND CONCLUSIONS
Meniere's disease is characterised by intermittent episodes of vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural pressure. The aetiology and pathogenesis remain unknown. Proposed theories of causation include viral infections and immune system-mediated mechanisms. The immune response in Meniere's disease is focused on inner ear antigens. Approximately one-third of Meniere's disease cases seem to be of an autoimmune origin although the …
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A Greco, A Gallo, M Fusconi, C Marinelli, GF Macri… - Autoimmunity reviews, 2012
