作者
Shima Parsa, Vahid Mogharab, Mohsen Ebrahimi, Sayyed Reza Ahmadi, Behzad Shahi, Neema John Mehramiz, Mahdi Foroughian, Mohammad Zarenezhad, Navid Kalani, Mohammad Hashem Abdi, Farshid Javdani, Pouyan Keshavarz, Naser Hatami
发表日期
2021/4/30
期刊
International journal of biological macromolecules
卷号
177
页码范围
204-210
出版商
Elsevier
简介
Background
Given the observed olfactory and gustatory dysfunctions in patients with COVID-19 and recent findings on taste receptors possible important activities in the immune system, we elected to estimate the correlation between COVID-19 mortality and polymorphism of a particular type of bitter taste receptor gene called TAS2R38, in a worldwide epidemiological point of view.
Methods
Pooled rate of each of the rs713598, rs1726866, rs10246939, and PAV/AVI polymorphisms of the TAS2R38 gene was obtained in different countries using a systematic review methodology and its relationship with the mortality of COVID-19. Data were analyzed by the comprehensive meta-analysis software and SPSS.
Results
There was only a significant reverse Pearson correlation in death counts and PAV/AVI ratio, p = 0.047, r = −0.503. Also, a significant reverse correlation of PAV/AVI ratio and death rate was seen, r = −0.572 p …
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S Parsa, V Mogharab, M Ebrahimi, SR Ahmadi… - International journal of biological macromolecules, 2021