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Stroke is a medical condition characterized by a sudden, localized neurological impairment caused by damage to the central nervous system due to either a blockage or bleeding in the blood vessels. This process leads to increased oxidation, which can exacerbate brain damage. Flavonoids are compounds that are widely found in nature and are considered to have numerous health benefits. 7, 8‑dihydroxyflavone (7, 8‑DHF) is a flavonoid that has tropomyosin receptor kinase B agonist activity. However, the other beneficial activities of 7, 8‑DHF remain to be explored, particularly in neuron‑related diseases. The present study aimed to explore 7, 8‑DHF as an antioxidant agent using in vivo and in silico analyses. An in vivo experiment was conducted using Rattus novergicus, in which ischemia‑reperfusion brain injury was induced. A total of 30 rats were divided into the sham‑operated, control and treatment groups …