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Hepatic fat fraction (HFF) was measured in 28 lean/obese humans by single‐voxel proton spectroscopy (MRS), a two‐point Dixon (2PD), and a three‐point iterative decomposition of water and fat with echo asymmetry and least‐squares estimation (IDEAL) method (3PI). For the lean, obese, and total subject groups, the range of HFF measured by MRS was 0.3–3.5% (1.1 ± 1.4%), 0.3–41.5% (11.7 ± 12.1), and 0.3–41.5% (10.1 ± 11.6%), respectively. For the same groups, the HFF measured by 2PD was −6.3–2.2% (−2.0 ± 3.7%), −2.4–42.9% (12.9 ± 13.8%), and −6.3–42.9% (10.5 ± 13.7%), respectively, and for 3PI they were 7.9–12.8% (10.1 ± 2.0%), 11.1–49.3% (22.0 ± 12.2%), and 7.9–49.3% (20.0 ± 11.8%), respectively. The HFF measured by MRS was highly correlated with those measured by 2PD (r = 0.954, P < 0.001) and 3PI (r = 0.973, P < 0.001). With the MRS data as a reference, the percentages of correct …