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Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown a role for this molecule and its LPA₁ receptor in the regulation of plasticity and neurogenesis in the adult brain. However, no systematic studies have been conducted to investigate whether the LPA₁ receptor is involved in behavior. In this study, we studied the phenotype of maLPA₁‐null mice, which bear a targeted deletion at the lpa₁ locus, in a battery of tests examining neurologic performance, habituation in exploratory behavior in response to low and mild anxiety environments and spatial memory. MaLPA₁‐null mutants showed deficits in both olfaction and somesthesis, but not in retinal or auditory functions. Sensorimotor co‐ordination was impaired only in the equilibrium and grasping reflexes. The mice also showed impairments in neuromuscular strength and analgesic response. No …