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The aim of this study has fundamental importance for the fact belonging to the Public Health area as well as Oral Pathology, whose knowledge favors the prevention, diagnosis, prognosis and a correct therapeutic to be instituted for each case. A retrospective study of 1963 oral and maxillofacial lesions diagnosed by the Histopathology Laboratory of the Scholl of Dentistry–UnicenP was carried out over a 3-year period, with an analysis of prevalence of these lesions, correlating them to age and sex, through a study of the respective lauds of histopathologic diagnosis. From the results, 82 different diagnoses were observed. The epidemiologic profile of these patients was characterized by female (65, 82%), with a greater frequency on the 5th decade of life (24%), average of 44, 2 year-old age. Data evidenced Inflammatory Fibrous Hyperplasia the most prevalent lesion (30, 6%), followed by Fibroma (21, 29%), Radicular Cyst (5, 2%) and Mucocele (5, 04%).