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Houston, Texas is a major U.S. urban and industrial area where poor air quality is unevenly distributed and a disproportionate share is located in low-income, non-white, and Hispanic neighborhoods. We have traditionally lacked city-wide observations to fully describe these spatial heterogeneities in Houston and in cities globally, especially for reactive gases like nitrogen dioxide (NO₂). Here, we analyze novel high-spatial-resolution (250 m × 500 m) NO₂ vertical columns measured by the NASA GCAS airborne spectrometer as part of the September-2013 NASA DISCOVER-AQ mission and discuss differences in population-weighted NO₂ at the census-tract level. Based on the average of 35 repeated flight circuits, we find 37 ± 6% higher NO₂ for non-whites and Hispanics living in low-income tracts (LIN) compared to whites living in high-income tracts (HIW) and report NO₂ disparities separately by race ethnicity (11 …