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Background

Research gaps prevent systematic reviewers from making conclusions and, ultimately, limit our ability to make informed health care decisions. While there are well-defined methods for conducting a systematic review, there has been no explicit process for the identification of research gaps from systematic reviews. In a prior project we developed a framework to facilitate the systematic identification and characterization of research gaps from systematic reviews. This framework uses elements of PICOS (Population, Intervention, Comparison, Outcomes, Setting) to describe the gaps and categorizes the reasons for the gaps as (A) insufficient or imprecise information,(B) biased information,(C) inconsistent or unknown consistency results, and/or (D) not the right information.

Objective

To further develop and evaluate a framework for the identification and characterization of research gaps from systematic reviews.

Methods

We conducted two types of evaluation:(1) We applied the framework to existing systematic reviews, and (2) Evidence-based Practice Centers (EPCs) applied the framework either during a systematic review or during a future research needs project (FRN). EPCs provided feedback on the framework using an evaluation form.

Results

Our application of the framework to 50 systematic reviews identified about 600 unique research gaps. Key issues emerging from this evaluation included the need to clarify instructions for dealing with multiple comparisons (lumping vs. splitting) and need for guidance on applying the framework retrospectively. We received evaluation forms from seven EPCs. EPCs applied the framework in 8 projects …