作者
Lucas Leite Cunha, Marjory Alana Marcello, Suely Nonogaki, Elaine Cristina Morari, Fernando Augusto Soares, José Vassallo, Laura Sterian Ward
发表日期
2015/8
期刊
Clinical endocrinology
卷号
83
期号
2
页码范围
246-253
简介
Background/objective
There is an increasing rate of papillary thyroid carcinomas that may never progress to cause symptoms or death. Predicting outcome and determining tumour aggressiveness could help diminish the number of patients submitted to aggressive treatments. We aimed to evaluate whether markers of the immune system response and of tumour‐associated inflammation could predict outcome of differentiated thyroid cancer (DTC) patients.
Design
Retrospective cohort study.
Patients
We studied 399 consecutive patients, including 325 papillary and 74 follicular thyroid carcinomas.
Measurements
Immune cell markers were evaluated using immunohistochemistry, including tumour‐associated macrophages (CD68) and subsets of tumour‐infiltrating lymphocytes (TIL), such as CD3, CD4, CD8, CD16, CD20, CD45RO, GRANZYME B, CD69 and CD25. We also investigated the expression of …
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LL Cunha, MA Marcello, S Nonogaki, EC Morari… - Clinical endocrinology, 2015