作者
Didier Smadja, Nicolas Chausson, Julien Joux, Martine Saint-Vil, Aïssatou Signaté, Mireille Edimonana, Séverine Jeannin, Blaise Bartoli, Mathieu Aveillan, Philippe Cabre, Stéphane Olindo
发表日期
2011/6
期刊
Stroke
卷号
42
期号
6
页码范围
1644-1647
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
Intravenous tissue-type plasminogen activator (IV tPA) frequently fails to recanalize proximal middle cerebral artery (MCA-M1) obstructions, preventing favorable outcomes. Only neurointerventional procedures prevail in these cases, but well-equipped centers remain scarce. A new therapeutic strategy consisting of a second IV thrombolysis with low-dose tenecteplase was applied.
Methods
Consecutive patients with an MCA-M1 occlusion that did not reopen at the end of IV tPA perfusion received IV tenecteplase (0.1 mg/kg). Partial or complete thrombolysis in myocardial infarction recanalization (Thrombolysis In Myocardial Infarction grade 2/3) and intracerebral hemorrhage were assessed by magnetic resonance imaging ≈24 hours later. Clinical outcomes at 3 months were evaluated with the modified Rankin score.
Results
Among 40 patients with MCA-M1 occlusions who received IV tPA …
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D Smadja, N Chausson, J Joux, M Saint-Vil, A Signaté… - Stroke, 2011