作者
Gaspard Gerschenfeld, Didier Smadja, Guillaume Turc, Stephane Olindo, François-Xavier Laborne, Marion Yger, Jildaz Caroff, Bruno Gonçalves, Pierre Seners, Marie Cantier, Yann l'Hermitte, Manvel Aghasaryan, Cosmin Alecu, Gaultier Marnat, Wagih Ben Hassen, Erwah Kalsoum, Frédéric Clarençon, Michel Piotin, Laurent Spelle, Christian Denier, Igor Sibon, Sonia Alamowitch, Nicolas Chausson, TETRIS Study Group
发表日期
2021/11/30
期刊
Neurology
卷号
97
期号
22
页码范围
e2173-e2184
出版商
Lippincott Williams & Wilkins
简介
Background and Objectives
To investigate in routine care the efficacy and safety of IV thrombolysis (IVT) with tenecteplase prior to mechanical thrombectomy (MT) in patients with large vessel occlusion acute ischemic strokes (LVO-AIS), either secondarily transferred after IVT or directly admitted to a comprehensive stroke center (CSC).
Methods
We retrospectively analyzed clinical and procedural data of patients treated with 0.25 mg/kg tenecteplase within 270 minutes of LVO-AIS who underwent brain angiography. The main outcome was 3-month functional independence (modified Rankin Scale score ≤2). Recanalization (revised Treatment in Cerebral Ischemia score 2b–3) was evaluated before (pre-MT) and after MT (final).
Results
We included 588 patients (median age 75 years [interquartile range (IQR) 61–84]; 315 women [54%]; median NIH Stroke Scale score 16 [IQR 10–20]), of whom 520 (88%) were …
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