查看文章

Materials and Methods:

We performed a randomized, prospective, controlled trial in 54 septic shock patients, with persistent hypotension despite adequate volume resuscitation and continued dopamine infusion~ 25μg/kg/h. Patients were randomly allocated into two groups to receive either norepinephrine or phenylephrine infusion (n= 27 each) titrated to achieve a target of SBP> 90mm Hg, MAP> 75 mm Hg, SVRI> 1100 dynes. s/cm5m2, CI> 2.8 L/min/m2, DO2I> 550 ml/min/m2, and VO2I> 150 ml/min/m2 for continuous 6 h. All the parameters were recorded every 30 min and increment in dose of studied drug was done in the specified dose range if targets were not achieved. Data from pulmonary arterial and hepatic vein catheterization, thermodilution catheter, blood gas analysis, blood lactate levels, invasive blood pressure, and oxygen transport variables were compared with baseline values after achieving the …