查看文章

Background:

Reduction of postoperative nausea and vomiting (PONV) continues to be a major challenge in perioperative care in spite of introduction of newer antiemetics with better efficacy and safety profiles. Therefore, we evaluated the additive effect of oral midazolam and clonidine for PONV prophylaxis in granisetron premedicated patients undergoing laparoscopic cholecystectomy.

Materials and Methods:

In a prospective, randomized fashion, 120 selected cases were randomized into three groups: I, II or III to receive a tablet of midazolam (15 mg, n= 36), clonidine (150 mcg, n= 40), or glucose as placebo (5 g, n= 44) orally, 1 h before anesthesia. Occurrence of PONV along with need for rescue antiemetic during the first postoperative day was compared between groups as a primary outcome.

Results:

Episodes of PONV reduced significantly in Group II (15%) as compared to group I and III (22.2%, 59%) at various …