作者
Pooja Singh, Sandeep Chauhan, Gaurav Jain, Sachin Talwar, Neeti Makhija, Usha Kiran
发表日期
2013/1
期刊
World Journal for Pediatric and Congenital Heart Surgery
卷号
4
期号
1
页码范围
24-29
出版商
SAGE Publications
简介
Background
Volatile anesthetic agents may precondition the myocardium and protect against ischemia and infarction. Preconditioning by volatile anesthetic agents is well documented in adults but is underinvestigated in children. The present study compares the effect of preconditioning in children by three volatile anesthetic agents along with several other variables associated with cardioprotection.
Method
Eighty children scheduled for ventricular septal defect closure under cardioplegic arrest were assigned to preconditioning for five minutes after commencement of cardiopulmonary bypass (CPB) with one minimum alveolar concentration (MAC) of one of the following agents: isoflurane, sevoflurane, desflurane, or placebo (oxygen-air mixture). The plasma concentration of creatine kinase MB (CK-MB) was determined after initiation of CPB, and again 6 and 24 hours after admission to the intensive care unit (ICU …
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P Singh, S Chauhan, G Jain, S Talwar, N Makhija… - World Journal for Pediatric and Congenital Heart …, 2013