作者
Jens Kuhle, G Disanto, R Dobson, R Adiutori, L Bianchi, J Topping, Jonathan P Bestwick, Ute Christiane Meier, M Marta, G Dalla Costa, Tessel Runia, E Evdoshenko, N Lazareva, Eric Thouvenot, Pietro Iaffaldano, V Direnzo, Mohsen Khademi, Fredrik Piehl, Manuel Comabella, M Sombekke, Joep Killestein, Harald Hegen, S Rauch, S D’Alfonso, José C Álvarez-Cermeño, P Kleinová, D Horáková, R Roesler, F Lauda, S Llufriu, T Avsar, U Uygunoglu, Ayse Altintas, S Saip, Til Menge, Cecília Rajda, R Bergamaschi, N Moll, M Khalil, Romain Marignier, Irena Dujmovic, H Larsson, C Malmestrom, Elio Scarpini, Chiara Fenoglio, S Wergeland, A Laroni, V Annibali, S Romano, AD Martínez, A Carra, M Salvetti, A Uccelli, Ø Torkildsen, KM Myhr, Daniela Galimberti, Konrad Rejdak, Jan Lycke, JL Frederiksen, Jelena Drulovic, Christian Confavreux, David Brassat, Christian Enzinger, S Fuchs, I Bosca, J Pelletier, C Picard, E Colombo, Diego Franciotta, T Derfuss, RLP Lindberg, Ö Yaldizli, László Vécsei, BC Kieseier, HP Hartung, P Villoslada, Aksel Siva, A Saiz, Hayrettin Tumani, E Havrdová, Luisa María Villar, M Leone, Nadia Barizzone, Florian Deisenhammer, Charlotte Teunissen, X Montalban, M Tintoré, T Olsson, Maria Trojano, S Lehmann, G Castelnovo, S Lapin, Rogier Hintzen, L Kappos, Roberto Furlan, Vittorio Martinelli, Giancarlo Comi, SV Ramagopalan, Gavin Giovannoni
发表日期
2015/7
期刊
Multiple Sclerosis Journal
卷号
21
期号
8
页码范围
1013-1024
出版商
Sage Publications
简介
Background and objective
We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort.
Methods
Thirty-three centres provided serum samples from 1047 CIS cases with at least two years’ follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum 25-hydroxyvitamin D3 (25-OH-D), cotinine and IgG titres against Epstein-Barr nuclear antigen 1 (EBNA-1) and cytomegalovirus were tested for association with risk of CDMS.
Results
At median follow-up of 4.31 years, 623 CIS cases converted to CDMS. Predictors of conversion in multivariable analyses were OCB (HR = 2.18, 95% CI = 1.71–2.77, p < 0.001), number of T2 lesions (two to nine lesions vs 0/1 lesions: HR = 1.97, 95% CI = 1.52–2.55, p < 0 …
学术搜索中的文章
J Kuhle, G Disanto, R Dobson, R Adiutori, L Bianchi… - Multiple Sclerosis Journal, 2015