作者
Caroline Malle, Tomohisa Tada, Kristin Steigerwald, Giovanni J Ughi, Tibor Schuster, Masataka Nakano, Steffen Massberg, Johannes Jehle, Giulio Guagliumi, Adnan Kastrati, Renu Virmani, Robert A Byrne, Michael Joner
发表日期
2013/6
期刊
Arteriosclerosis, thrombosis, and vascular biology
卷号
33
期号
6
页码范围
1376-1383
出版商
Lippincott Williams & Wilkins
简介
Objective
To validate optical coherence tomography (OCT) imaging for assessment of vascular healing in a preclinical animal model and human autopsy cases and to translate the findings to the assessment of vascular healing after drug-eluting stent implantation in clinical practice.
Approach and Results
Drug-eluting and bare metal stents were imaged 28 and 42 days after implantation in atherosclerotic rabbits using OCT and simultaneously evaluated by histology. After coregistration with histology, gray-scale signal intensity (GSI) was measured for identified mature or immature neointimal tissue. Autopsy specimens were imaged with OCT and GSI values correlated with histology. Finally, prospective OCT imaging and GSI measurements were acquired in 10 patients undergoing follow-up 6 months after stenting with drug-eluting stents. Histopathologic and OCT morphometric analysis of implanted stents showed …
学术搜索中的文章
C Malle, T Tada, K Steigerwald, GJ Ughi, T Schuster… - Arteriosclerosis, thrombosis, and vascular biology, 2013