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Interethnic differences in cytochrome P450 polymorphism might be responsible, at least in part, for the variations in drug disposition between ethnic groups. Of the various CYP2C9 alleles, CYP2C9* 2 and CYP2C9* 3 have been reported to have altered catalytic activities compared to the wild-type CYP2C9* 1. The present study is aimed at analysing the CYP2C9 polymorphism in a Mexican-American compared with a Spanish population. Differences between the two populations of healthy volunteers, Mexican-Americans (n= 98 subjects) and Spaniards (n= 102 subjects), regarding the CYP2C9 allele frequencies have been found. CYP2C9 genotypes among the studied Mexican-American population are in equilibrium. The 95% CI were, respectively, 0.81–0.90 for CYP2C9* 1 (n= 169), 0.05–0.13 for CYP2C9* 2 (n= 16) and 0.031–0.10 for CYP2C9* 3 (n= 11). CYP2C9* 4,* 5 and* 6 were found in none of the studied …