作者
A Llerena, P Dorado, F O'kirwan, R Jepson, J Licinio, ML Wong
发表日期
2004/12
期刊
The Pharmacogenomics Journal
卷号
4
期号
6
页码范围
403-406
出版商
Nature Publishing Group
简介
Interethnic differences in cytochrome P450 polymorphism might be responsible, at least in part, for the variations in drug disposition between ethnic groups. Of the various CYP2C9 alleles, CYP2C9* 2 and CYP2C9* 3 have been reported to have altered catalytic activities compared to the wild-type CYP2C9* 1. The present study is aimed at analysing the CYP2C9 polymorphism in a Mexican-American compared with a Spanish population. Differences between the two populations of healthy volunteers, Mexican-Americans (n= 98 subjects) and Spaniards (n= 102 subjects), regarding the CYP2C9 allele frequencies have been found. CYP2C9 genotypes among the studied Mexican-American population are in equilibrium. The 95% CI were, respectively, 0.81–0.90 for CYP2C9* 1 (n= 169), 0.05–0.13 for CYP2C9* 2 (n= 16) and 0.031–0.10 for CYP2C9* 3 (n= 11). CYP2C9* 4,* 5 and* 6 were found in none of the studied …
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