作者
Roger Chou, Judith A Turner, Emily B Devine, Ryan N Hansen, Sean D Sullivan, Ian Blazina, Tracy Dana, Christina Bougatsos, Richard A Deyo
发表日期
2015/2/17
来源
Annals of internal medicine
卷号
162
期号
4
页码范围
276-286
出版商
American College of Physicians
简介
Background
Increases in prescriptions of opioid medications for chronic pain have been accompanied by increases in opioid overdoses, abuse, and other harms and uncertainty about long-term effectiveness.
Purpose
To evaluate evidence on the effectiveness and harms of long-term (>3 months) opioid therapy for chronic pain in adults.
Data Sources
MEDLINE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, PsycINFO, and CINAHL (January 2008 through August 2014); relevant studies from a prior review; reference lists; and ClinicalTrials.gov.
Study Selection
Randomized trials and observational studies that involved adults with chronic pain who were prescribed long-term opioid therapy and that evaluated opioid therapy versus placebo, no …
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