作者
Lior M Elkaim, Naif M Alotaibi, Alissa Sigal, Haifa M Alotaibi, Nir Lipsman, Suneil K Kalia, Darcy L Fehlings, Andres M Lozano, George M Ibrahim, North American Pediatric DBS Collaboration, Alexander G Weil, Aria Fallah, Anthony C Wang, Albert Tu, Sami Obaid
发表日期
2019/1
来源
Developmental Medicine & Child Neurology
卷号
61
期号
1
页码范围
49-56
简介
Aim
We performed a meta‐analysis with individual participant data of deep brain stimulation (DBS) for dystonia in children and young people.
Method
Three databases (PubMed, Embase, and Web of Science) were queried from January 1999 to August 2017 with no language restrictions to identify case studies and cohort studies reporting on pediatric patients (age ≤21y) with dystonia. The primary outcomes were changes in Burke‐Fahn‐Marsden (BFM) or Barry‐Albright Dystonia Scale scores. A mixed‐effects regression was used to identify associations between clinical covariates and outcomes.
Results
Of 2509 citations reviewed, 72 articles (321 children) were eligible. At last follow‐up (median 12mo, 25th centile=9.0; 75th centile=32.2), 277 (86.3%) patients showed improvement in dystonia, while 66.1 percent showed clinically significant (>20%) BFM Dystonia Rating Scale‐motor improvement. On …
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LM Elkaim, NM Alotaibi, A Sigal, HM Alotaibi… - Developmental Medicine & Child Neurology, 2019