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Atopic dermatitis (AD) is a chronic inflammatory skin disease with skin colonization by Staphylococcus aureus. Interleukin (IL)-22 triggers antimicrobial peptide (AMP) elaboration and enhances immunune responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of AMP production. We aimed to evaluate the impact of staphylococcal enterotoxins (SEA and SEB) on the Tc22/Th22 induction in the peripheral blood of AD patients and on CD4+/CD8+ T cells expressing IL-22 in AD skin. Our study showed inhibition of SEA and SEB response by Th22 cells (p≤ 0.05) in AD patients, and an enhanced response to the bacterial stimuli by Tc22 cells (p≤ 0.05). In AD skin, we detected increased IL-22 transcript expression and T lymphocytes expressing IL-22 (p≤ 0.01). Together, our results provide two major findings in response to staphylococcal enterotoxins in adults with AD …