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Fatigue is the most common symptom experienced by patients during the cancer trajectory from diagnosis to the end of life and is defined as a distressing, persistent, subjective sense of physical, emotional and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent physical activity and that interferes with usual functioning. 1, 2 Cancer-related fatigue (CRF) is different from other types of fatigue by its severity and persistence and the inability to alleviate it through rest or sleep. CRF affects almost 65% of patients with cancer; over two-thirds of these patients describe CRF as severe for at least 6 months and one-third reports this as persistent fatigue for a number of years after treatment. 3, 4, 5 Up to 40% of patients report fatigue at cancer diagnosis, 80%–90% during chemotherapy (ChT) and/or radiotherapy (RT), in particular 17%–21% during ChT alone and 33%–53 …