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We combined information from functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) to assess which cortical areas and in which temporal order show macroscopic activation after right median nerve stimulation. Five healthy subjects were studied with the two imaging modalities, which both revealed significant activation in the contra‐ and ipsilateral primary somatosensory cortex (SI), the contra‐ and ipsilateral opercular areas, the walls of the contralateral postcentral sulcus (PoCS), and the contralateral supplementary motor area (SMA). In fMRI, two separate foci of activation in the opercular cortex were discerned, one posteriorly in the parietal operculum (PO), and one anteriorly near the insula or frontal operculum (anterior operculum, AO). The activation sites from fMRI were used to constrain the solution of the inverse problem of MEG, which allowed us to construct a model of the …