作者
Delaram Moghadam, Reza Zarei, Mohsen Tatar, Zahra Khoshdel, Farideh J Mashayekhi, Fakhraddin Naghibalhossaini
发表日期
2022/1/1
期刊
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents)
卷号
22
期号
2
页码范围
395-403
出版商
Bentham Science Publishers
简介
Background
Previous studies have provided strong evidence for the anticancer activity of berry fruits.
Objective
In this study, we investigated the effects of blackberry juice and three berry- polyphenolic compounds on cell proliferation and telomerase activity in human hepatoma HepG2 and normal peripheral blood mononuclear cells (PBMCs).
Methods
The cell viability and telomerase activity were measured by MTT and TRAP assay, respectively. Berry effects on the expression of genes were determined by quantitative RT-PCR assay.
Results
Blackberry, gallic acid, and resveratrol inhibited proliferation of both HepG2 and PBMC cells in a dosedependent manner. Resveratrol was more effective than gallic acid for reducing the viability of HepG2 cells, but both showed the same level of growth inhibition in PBMC cells. Berry, resveratrol, and gallic acid significantly inhibited telomerase activity in HepG2 cells. The …
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D Moghadam, R Zarei, M Tatar, Z Khoshdel… - Anti-Cancer Agents in Medicinal Chemistry (Formerly …, 2022