查看文章

Nanoemulsions (NEs) possess several advantages and have applications in controlled drug delivery and targeting. Pumpkin seed oil (PSO) oral NEs were dispensed with the objective of improving its oral bioavailability and prolonging its therapeutic efficacy. Phase diagrams were constructed. Eighteen formulations were selected from Labrafac™ PG phase diagrams. They passed thermodynamic stability tests and 10 out of them passed dispersibility tests in distilled water and 0.1 N HCl. Four formulations were compatible with PSO and showed total phenolic content ranging from 5.71 to 6.51 mg/kg of the incorporated PSO, expressed as gallic acid equivalent (GAE). The selected formulations revealed percolative electric conductivity, physiologically compatible pH, globule size < 400 nm, optimum polydispersity index (PDI), negatively charged zeta potential values, and were sterically stabilized by Tween 80. The …