作者
Sally Arai, Mukta Arora, Tao Wang, Stephen R Spellman, Wensheng He, Daniel R Couriel, Alvaro Urbano-Ispizua, Corey S Cutler, Andrea A Bacigalupo, Minoo Battiwalla, Mary E Flowers, Mark B Juckett, Stephanie J Lee, Alison W Loren, Thomas R Klumpp, Susan E Prockup, Olle TH Ringdén, Bipin N Savani, Gérard Socié, Kirk R Schultz, Thomas Spitzer, Takanori Teshima, Christopher N Bredeson, David A Jacobsohn, Robert J Hayashi, William R Drobyski, Haydar A Frangoul, Görgün Akpek, Vincent T Ho, Victor A Lewis, Robert Peter Gale, John Koreth, Nelson J Chao, Mahmoud D Aljurf, Brenda W Cooper, Mary J Laughlin, Jack W Hsu, Peiman Hematti, Leo F Verdonck, Melhelm M Solh, Maxim Norkin, Vijay Reddy, Rodrigo Martino, Shahinaz Gadalla, Jenna D Goldberg, Philip L McCarthy, José A Pérez-Simón, Nandita Khera, Ian D Lewis, Yoshiko Atsuta, Richard F Olsson, Wael Saber, Edmund K Waller, Didier Blaise, Joseph A Pidala, Paul J Martin, Prakash Satwani, Martin Bornhäuser, Yoshihiro Inamoto, Daniel J Weisdorf, Mary M Horowitz, Steven Z Pavletic
发表日期
2015/2/1
期刊
Biology of Blood and Marrow Transplantation
卷号
21
期号
2
页码范围
266-274
出版商
Elsevier
简介
Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) over time. This study used the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe time trends for cGVHD incidence, nonrelapse mortality, and risk factors for cGVHD. The 12-year period was divided into 3 intervals, 1995 to 1999, 2000 to 2003, and 2004 to 2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. Multivariate analysis showed an increased incidence of cGVHD in more recent years (odds ratio = 1.19, P < .0001), and this trend was still seen when adjusting for donor type, graft type, or conditioning intensity. In patients with cGVHD, nonrelapse mortality has decreased over time, but at 5 years there were no …
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S Arai, M Arora, T Wang, SR Spellman, W He… - Biology of Blood and Marrow Transplantation, 2015