作者
Martin A Birchall, Michael Bailey, Danuta Gutowska-Owsiak, Nikki Johnston, Charlotte F Inman, Christopher R Stokes, Gregory Postma, Laszlo Pazmany, Jamie A Koufman, Anne Phillips, Louisa E Rees
发表日期
2008/12
期刊
Annals of Otology, Rhinology & Laryngology
卷号
117
期号
12
页码范围
891-895
出版商
SAGE Publications
简介
Objectives
Extraesophageal reflux is common. The treatment costs are high, and there are associations with other diseases, including laryngeal cancer. Our studies of the mucosal immune response to this common inflammatory disease suggest an important role for the nonclassic antigen-presenting molecule CD1d in the response to inflammation. This study was performed to further explore the relationship between the CD1d–NKT cell–iGb3 axis and reflux.
Methods
We carried out a prospective study of laryngeal biopsies from 12 patients with laryngopharyngeal reflux and 11 controls. Quantitative multiple-color immunofluorescence using antibodies for lymphocytes (CD3, CD161) and classic and nonclassic major histocompatibility complex (I, II, β2m, CD1d) was performed, and univariate and multivariate analysis and co-localization measurements were applied.
Results
Epithelial major histocompatibility complex …
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