作者
Anne K Krug, Raivo Kolde, John A Gaspar, Eugen Rempel, Nina V Balmer, Kesavan Meganathan, Kinga Vojnits, Mathurin Baquié, Tanja Waldmann, Roberto Ensenat-Waser, Smita Jagtap, Richard M Evans, Stephanie Julien, Hedi Peterson, Dimitra Zagoura, Suzanne Kadereit, Daniel Gerhard, Isaia Sotiriadou, Michael Heke, Karthick Natarajan, Margit Henry, Johannes Winkler, Rosemarie Marchan, Luc Stoppini, Sieto Bosgra, Joost Westerhout, Miriam Verwei, Jaak Vilo, Andreas Kortenkamp, Jürgen Hescheler, Ludwig Hothorn, Susanne Bremer, Christoph van Thriel, Karl-Heinz Krause, Jan G Hengstler, Jörg Rahnenführer, Marcel Leist, Agapios Sachinidis
发表日期
2013/1
期刊
Archives of toxicology
卷号
87
页码范围
123-143
出版商
Springer-Verlag
简介
Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based on cell death, but rather on minor changes relating to cell differentiation or communication. The fields of DNT/RT would greatly benefit from in vitro tests that allow the identification of toxicant-induced changes of the cellular proteostasis, or of its underlying transcriptome network. Therefore, the ‘human embryonic stem cell (hESC)-derived novel alternative test systems (ESNATS)’ European commission research project established RT tests based on defined differentiation protocols of hESC and their progeny. Valproic acid (VPA) and methylmercury (MeHg) were used as positive control compounds to address the following fundamental questions: (1) Does transcriptome analysis allow discrimination of the two compounds? (2) How does analysis of …
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AK Krug, R Kolde, JA Gaspar, E Rempel, NV Balmer… - Archives of toxicology, 2013
