作者
Sonali R Gnanenthiran, Austin CC Ng, Robert G Cumming, David B Brieger, David G le Couteur, Louise M Waite, Markus Seibel, David J Handelsman, Vasi Naganathan, Leonard Kritharides, Fiona M Blyth
发表日期
2022/6/1
期刊
Canadian Journal of Cardiology
卷号
38
期号
6
页码范围
745-753
出版商
Elsevier
简介
Background
Anemia is associated with increased risk of all-cause mortality in older populations. However, the relationship between hemoglobin and major adverse cardiovascular events (MACE), and whether this is modulated by frailty, is unclear.
Methods
CHAMP (Concord Health and Ageing in Men Project) is a prospective study of community-dwelling men aged ≥ 70 years. The relationship between hemoglobin and 7-year MACE was analysed by means of Cox regression. The Youden index was used to determine the optimal hemoglobin cutoff point in predicting MACE. Frailty was assessed with the use of the Fried criteria.
Results
The cohort comprised 1604 men (mean ± SD age 76.9 ± 5.5 years). Decreasing hemoglobin was associated with increased comorbidity, frailty, and MACE (P < 0.001), with 140 g/L the optimal cutoff point for predicting MACE. Hemoglobin, age, and frailty independently predicted MACE …
学术搜索中的文章
SR Gnanenthiran, ACC Ng, RG Cumming, DB Brieger… - Canadian Journal of Cardiology, 2022
D Massarella, E Oechslin - The Canadian Journal of Cardiology, 2021