作者
Stefano Sartori, Margherita Nosadini, Elisabetta Cesaroni, Raffaele Falsaperla, Giuseppe Capovilla, Francesca Beccaria, Maria Margherita Mancardi, Giuseppe Santangelo, Leandra Giunta, Clementina Boniver, Gaetano Cantalupo, Alberto Cappellari, Paola Costa, Bernardo Dalla Bernardina, Robertino Dilena, Maria Grazia Natali Sora, Maria Federica Pelizza, Dario Pruna, Domenico Serino, Francesca Vanadia, Federico Vigevano, Nelia Zamponi, Caterina Zanus, Irene Toldo, Agnese Suppiej
发表日期
2015/7/1
期刊
European Journal of Paediatric Neurology
卷号
19
期号
4
页码范围
453-463
出版商
WB Saunders
简介
Background
Given the rarity of this condition, especially in children, there is a paucity of large reported paediatric case series of anti-N-methyl-d-aspartate receptor encephalitis.
Methods
To contribute to define the features of this condition, we describe retrospectively a new nationwide case series of 20 children (50% females), referred by 13 Italian centres.
Results
Mean age at onset was 8 years (range 3–17). Prodromal symptoms were reported in 31.6%; onset was with neurological symptoms in 70%, and with behavioural/psychiatric disturbances in 30%. Most patients developed a severe clinical picture (90%), and 41% experienced medical complications; children 12–18 years old seemed to be more severe and symptomatic than younger patients. All children received first-line immune therapy; second-line treatment was administered to 45%. Relapses occurred in 15%. At last follow-up (mean 23.9 months, range 5 …
学术搜索中的文章
S Sartori, M Nosadini, E Cesaroni, R Falsaperla… - European Journal of Paediatric Neurology, 2015
