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Background:

Intraoperatively administered tranexamic acid (TXA) lessens blood loss during orthopedic and cardiovascular surgery. Its use for craniosynostosis surgery warrants investigation. Therefore, we analyzed our use of TXA during minimally invasive (MI) and open craniosynostosis procedures.

Methods:

Fifty-six patients were retrospectively studied: 20 in the MI group, 10 receiving TXA; 36 in the open group, 16 receiving TXA. Study variables were weight-adjusted estimated blood loss (EBL) and calculated blood loss (CBL), transfusion and incidence, transfusion volume, and complications. Calculated blood loss was determined by a novel formula based on red cell mass.

Results:

In the MI group, median EBL was significantly lower for TXA recipients (9.62 vs 15.94 mL/kg, P= 0.0231), whereas median CBL was not (36.59 vs 34.12 mL/kg, P= 0.7976). Transfusion incidences were 80% TXA versus 100% control …