作者
Larissa Sweeny, Sallie M Long, Patrik Pipkorn, Mark K Wax, Carissa M Thomas, Joseph M Curry, Sara Yang, Daniel Lander, Farshad Chowdhury, Dev Amin, Anne C Kane, Brett A Miles, Andrew Salama, Steven B Cannady, Kendall Tasche, Derek Mann, Ryan Jackson
发表日期
2024/1/31
期刊
Head & Neck
出版商
John Wiley & Sons, Inc.
简介
Background
Medication related osteonecrosis of the jaw (MRONJ) requiring free flap (FF) reconstruction is uncommon with limited reported findings.
Methods
Multicenter, retrospective case series of 49 consecutive adult patients presenting with advanced MRONJ requiring FF reconstruction from 2010 to 2022. Perioperative complications and outcomes were analyzed.
Results
Eighty‐two percent (n = 40) of cases were of the mandible and 18% (n = 9) were of the maxilla. The mean follow‐up was 15 months (±19.6). The majority of FF survived (96%, n = 47). FF reconstructions of the maxilla were more likely to require postoperative debridement (56%, 95% CI [27, 81%] vs. 15%, 95% CI [7, 25%], p = 0.008) or develop intraoral bone exposure (56%, 95% CI [27, 81%] vs. 18%, 95% CI [9, 27%], p = 0.02). Most patients (71%, n = 35) received preoperative antibiotics which was associated with a higher …
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L Sweeny, SM Long, P Pipkorn, MK Wax, CM Thomas… - Head & Neck, 2024