作者
Efstathios Antoniou, Georgios Antonios Margonis, Anastasios Angelou, Anastasia Pikouli, Paraskevi Argiri, Ioannis Karavokyros, Apostolos Papalois, Emmanouil Pikoulis
发表日期
2016/11/1
来源
Annals of medicine and surgery
卷号
11
页码范围
9-15
出版商
No longer published by Elsevier
简介
Background
Despite recent advances the pathogenesis of Crohn's disease remains incompletely understood. A variety of animal models have been utilized in an effort to provide further insights and develop more therapeutic options. In order to simulate, to an extent, the pathogenesis and the clinical course of the disease, TNBS induced colitis is often used. Various approaches for inducing TNBS -colitis have been described in the literature.
Methods/results
In this review, we sought to present the animal model of TNBS induced colitis and outline the pathogenesis, pathophysiology, clinical course and pathological characteristics of the model. Furthermore, we describe the differences among those protocols regarding types of animals and colitis induction.
Data sources
The MEDLINE database was thoroughly searched using the keywords: TNBS, colitis, Crohn's disease, animal model. Two investigators independently …
学术搜索中的文章
E Antoniou, GA Margonis, A Angelou, A Pikouli, P Argiri… - Annals of medicine and surgery, 2016
