作者
Praveen Kumar-M, Shubhra Mishra, Daya Krishna Jha, Jayendra Shukla, Arup Choudhury, Ritin Mohindra, Harshal S Mandavdhare, Usha Dutta, Vishal Sharma
发表日期
2020/9
来源
Hepatology international
卷号
14
页码范围
711-722
出版商
Springer India
简介
Background
Liver function derangements have been reported in coronavirus disease (COVID-19), but reported rates are variable.
Methods
We searched PubMed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence, stratified prevalence based on severity, estimated risk ratio (RR), and estimated standardized mean difference (SMD) of liver function parameters in severe as compared to non-severe COVID. Random effect method utilizing inverse variance approach was used for pooling the data.
Results
In all, 128 studies were included. The most frequent abnormalities were hypoalbuminemia [61.27% (48.24–72.87)], elevations of gamma-glutamyl transferase (GGT) [27.94% (18.22–40.27)], alanine aminotransferase (ALT) [23.28% (19.92–27.01)], and aspartate aminotransferase (AST) [23.41% (18.84–28.70)]. Furthermore, the relative risk of …
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P Kumar-M, S Mishra, DK Jha, J Shukla, A Choudhury… - Hepatology international, 2020
