作者
Anuraag Jena, Shubhra Mishra, Parakkal Deepak, Praveen Kumar-M, Aman Sharma, Yusuf I Patel, Nicholas A Kennedy, Alfred HJ Kim, Vishal Sharma, Shaji Sebastian
发表日期
2022/1/1
来源
Autoimmunity reviews
卷号
21
期号
1
页码范围
102927
出版商
Elsevier
简介
Objectives
The treatment for COVID-19 often utilizes immune-modulating drugs. These drugs are also used in immune mediated inflammatory diseases (IMIDs). We performed a systematic review about seroconversion after SARS-CoV-2 vaccination in patients with IMIDs and impact of various drugs on seroconversion rates.
Methods
Electronic databases were searched to identify relevant studies reporting seroconversion rates following SARS-CoV-2 vaccination in IMIDs. We calculated the pooled seroconversion rates after a single or two doses of vaccination, pooled seroconversion rates in patients with specific IMIDs, and rates in patients on various drugs/drug classes.
Results
Twenty-five studies were included in the systematic review. The pooled seroconversion rates after two doses of mRNA vaccination were higher (83.1, 95%CI: 74.9–89.0, I2 = 90%) as compared to a single dose (69.3, 52.4–82.3, I2 = 95%). The …
学术搜索中的文章
A Jena, S Mishra, P Deepak, P Kumar-M, A Sharma… - Autoimmunity reviews, 2022
