作者
Ahmed Abdel-Latif, Roberto Bolli, Imad M Tleyjeh, Victor M Montori, Emerson C Perin, Carlton A Hornung, Ewa K Zuba-Surma, Mouaz Al-Mallah, Buddhadeb Dawn
发表日期
2007/5/28
来源
Archives of internal medicine
卷号
167
期号
10
页码范围
989-997
出版商
American Medical Association
简介
Background
The results from small clinical studies suggest that therapy with adult bone marrow (BM)–derived cells (BMCs) reduces infarct size and improves left ventricular function and perfusion. However, the effects of BMC transplantation in patients with ischemic heart disease remains unclear.
Methods
We searched MEDLINE, EMBASE, Science Citation Index, CINAHL (Cumulative Index to Nursing and Allied Health), and the Cochrane Central Register of Controlled Trials (CENTRAL) (through July 2006) for randomized controlled trials and cohort studies of BMC transplantation to treat ischemic heart disease. We conducted a random-effects meta-analysis across eligible studies measuring the same outcomes.
Results
Eighteen studies (N = 999 patients) were eligible. The adult BMCs included BM mononuclear cells, BM mesenchymal stem cells, and BM-derived circulating progenitor cells. Compared with controls …
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A Abdel-Latif, R Bolli, IM Tleyjeh, VM Montori, EC Perin… - Archives of internal medicine, 2007