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Green and efficient extraction of natural products from biomass is considered an important area of interest in the pharmaceutical and biochemical industries. Recently, deep eutectic solvents (DESs) have been gaining increasing interest as sustainable and safe solvents. In this study, we aimed to provide a practical example using a popular traditional Chinese medicine, Flos sophorae, showcasing the tuneability of DESs as designer solvents to selectively and efficiently extract bioactive compounds from biomass. As a result, a solvent called PG-1 that was tailor-made from a 2 : 5 mixture of L-proline and glycerol using a freeze-drying method was more effective than methanol for extraction of quercetin, kaempferol, and isorhamnetin glycosides from Flos sophorae. With PG-1-based ultrasound-assisted extraction (UAE), operational conditions including the DES content in the extractant, the extractant-to-sample solid …