作者
Ying Tian, Sheri E Kelemen, Michael V Autieri
发表日期
2006/4
期刊
American Journal of Physiology-Cell Physiology
卷号
290
期号
4
页码范围
C1083-C1091
出版商
American Physiological Society
简介
Allograft inflammatory factor-1 (AIF-1) is a cytoplasmic, calcium-binding, inflammation-responsive scaffold protein. Several studies have reported increased AIF-1 expression in activated macrophages and have implicated AIF-1 as a marker of activated macrophages. However, the function of AIF-1 in macrophages and the mechanism whereby it participates in macrophage activation are unknown at this time. Immunohistochemical analysis colocalized AIF-1 expression with CD68-positive macrophages in atherosclerotic human coronary arteries. Subsequent experiments were designed to determine a role for AIF-1 in macrophage activation in response to atherogenic stimuli. Stimulation of human and murine macrophages with oxidized LDL significantly increased AIF-1 expression above basal levels. Stable transfection of AIF-1 small interfering RNA (siRNA) in macrophages reduced AIF-1 protein expression by 79 …
引用总数
学术搜索中的文章
Y Tian, SE Kelemen, MV Autieri - American Journal of Physiology-Cell Physiology, 2006