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Background:

This is the first study that aimed to determine the efficacy and safety of concurrent chemoradiation with weekly cisplatin±celecoxib 100 mg twice daily in locally advanced undifferentiated nasopharyngeal carcinoma.

Materials and Methods:

Eligible patients had newly diagnosed locally advanced (T3-T4, and/or N2-N3, M0) undifferentiated nasopharyngeal carcinoma, no prior therapy, Karnofsky performance status≥ 70, and normal organ function. The patients were assigned to receive 7 weeks concurrent chemoradiation (70 Gy) with weekly cisplatin 30 mg/m 2 with either celecoxib 100 mg twice daily,(study group, n= 26) or placebo (control group, n= 27) followed by adjuvant combined chemotherapy with cisplatin 70 mg/m 2 on day 1 plus 5-fluorouracil 750 mg/m 2/d with 8-h infusion on days 1-3, 3-weekly for 3 cycles.

Results:

Overall clinical response rate was 100% in both groups. Complete and partial …