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Meaning in life has been associated with well-being, optimal functioning, and positive psychotherapeutic outcomes. Meaning is best understood in terms of relationships between its three different structural components: cognitive, affective, and motivational. Using Reker and Wong’s (1988) model as theoretical background, the present study investigated the associations between trait affect, values structure, and sense of meaning. Participants included 383 college students from diverse ethnic and religious backgrounds. Multiple regression analysis explored the associations between affect, value structure and sense of meaning. Results indicated affect and value structure were significant predictors of meaning, with positive affect being the strongest predictor. Results are consistent with third-wave cognitive-behavioral therapies (eg, Acceptance and Commitment Therapy) and their emphasis on positive emotional experiences and values as important to the development of meaning and well-being.