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This study aimed to:(a) provide population-based estimates for the prevalence of mental disorders, including substance use, among undocumented Mexican immigrants;(b) assess for relevant comorbidities; and (c) identify sociodemographic, immigration and contextual vulnerabilities associated with meeting criteria for a disorder. This cross-sectional study used Respondent Driven Sampling (RDS) to collect and analyze data from clinical interviews with 248 undocumented Mexican immigrants residing near the California–Mexico border. The MINI Mini International Neuropsychiatric Interview was used as the primary outcome of interest. For all analyses, inferential statistics accounted for design effects and sample weights to produce weighted estimates. Logistic regression was used in multivariate analyses. Overall, 23% of participants met criteria for a disorder (95% CI= 17.1; 29.0). The …