作者
Jonathan A Shaffer, Donald Edmondson, Lauren Taggart Wasson, Louise Falzon, Kirsten Homma, Nchedcochukwu Ezeokoli, Peter Li, Karina W Davidson
发表日期
2014/4/1
来源
Psychosomatic medicine
卷号
76
期号
3
页码范围
190-196
出版商
LWW
简介
Objective
The aim of this study was to review the effects of vitamin D supplementation on depressive symptoms in randomized controlled trials. Although low vitamin D levels have been observationally associated with depressive symptoms, the effect of vitamin D supplementation as an antidepressant remains uncertain.
Methods
MEDLINE, CINAHL, AMED, PsycINFO, Scopus, The Cochrane Library, and references of included reports (through May 2013) were searched. Two independent reviewers identified and extracted data from randomized trials that compared the effect of vitamin D supplementation on depressive symptoms to a control condition. Two additional reviewers assessed study quality using The Cochrane Risk of Bias Tool. Seven trials (3191 participants) were included.
Results
Vitamin D supplementation had no overall effect on depressive symptoms (standardized mean difference [SMD], 0.14; 95 …
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JA Shaffer, D Edmondson, LT Wasson, L Falzon… - Psychosomatic medicine, 2014