作者
Daniel T Chang, Anand Swaminath, Margaret Kozak, Julie Weintraub, Albert C Koong, John Kim, Rob Dinniwell, James Brierley, Brian D Kavanagh, Laura A Dawson, Tracey E Schefter
发表日期
2011/9/1
期刊
Cancer
卷号
117
期号
17
页码范围
4060-4069
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
This study was undertaken to determine outcomes of stereotactic body radiotherapy for colorectal liver metastases in a pooled patient cohort.
METHODS
Patients with colorectal liver metastases from 3 institutions were included if they had 1 to 4 lesions, received 1 to 6 fractions of stereotactic body radiotherapy, and had radiologic imaging ≥3 months post‐treatment. Sixty‐five patients with 102 lesions treated from August 2003 to May 2009 were retrospectively analyzed. A tumor control probability (TCP) model was used to estimate the 3‐fraction dose required for >90% local control after converting the schedule into biologically equivalent dose (BED), single‐fraction equivalent dose, or linear quadratic model‐based single‐fraction dose.
RESULTS
Forty‐seven (72%) patients had ≥1 chemotherapy regimen before stereotactic body radiotherapy, and 27 (42%) patients had ≥2 regimens. The …
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