作者
Laura A Dawson, Brian D Kavanagh, Arnold C Paulino, Shiva K Das, Moyed Miften, X Allen Li, Charlie Pan, Randall K Ten Haken, Timothy E Schultheiss
发表日期
2010/3/1
来源
International Journal of Radiation Oncology* Biology* Physics
卷号
76
期号
3
页码范围
S108-S115
出版商
Elsevier
简介
The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation. The incidence of radiotherapy-associated kidney injury is likely underreported owing to its long latency and because the toxicity is often attributed to more common causes of kidney injury. The pathophysiology of radiation injury is poorly understood. Its presentation can be acute and irreversible or subtle, with a gradual progressive dysfunction over years. A variety of dose and volume parameters have been associated with renal toxicity and are reviewed to provide treatment guidelines. The available predictive models are suboptimal and require validation. Mitigation of radiation nephropathy with angiotensin-converting enzyme inhibitors and other compounds has been shown in animal models and, more recently, in patients.
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LA Dawson, BD Kavanagh, AC Paulino, SK Das… - International Journal of Radiation Oncology* Biology …, 2010