作者
James S Molton, Monica Chan, Shirin Kalimuddin, Jolene Oon, Barnaby E Young, Jenny G Low, Brenda MA Salada, Tau Hong Lee, Limin Wijaya, Dale A Fisher, Ezlyn Izharuddin, Tse Hsien Koh, Jeanette WP Teo, Prabha Unny Krishnan, Bien Peng Tan, Winston WL Woon, Ying Ding, Yuan Wei, Rachel Phillips, Rajesh Moorakonda, Kah Hung Yuen, Boon Piang Cher, Joanne Yoong, David C Lye, Sophia Archuleta
发表日期
2020/8/14
期刊
Clinical Infectious Diseases
卷号
71
期号
4
页码范围
952-959
出版商
Oxford University Press
简介
Background
Klebsiella pneumoniae liver abscess (KLA) is emerging worldwide due to hypermucoviscous strains with a propensity for metastatic infection. Treatment includes drainage and prolonged intravenous antibiotics. We aimed to determine whether oral antibiotics were noninferior to continued intravenous antibiotics for KLA.
Methods
This noninferiority, parallel group, randomized, clinical trial recruited hospitalized adults with liver abscess and K. pneumoniae isolated from blood or abscess fluid who had received ≤7 days of effective antibiotics at 3 sites in Singapore. Patients were randomized 1:1 to oral (ciprofloxacin) or intravenous (ceftriaxone) antibiotics for 28 days. If day 28 clinical response criteria were not met, further oral antibiotics were prescribed until clinical response was met. The primary endpoint was clinical cure assessed at week 12 and included a …
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JS Molton, M Chan, S Kalimuddin, J Oon, BE Young… - Clinical Infectious Diseases, 2020